Contract: Fixed term for 4 years with potential for further extension
A pioneering gene therapy innovation centre at the University of Sheffield is set to advance scientific discoveries into promising treatment options for millions of patients with life-threatening diseases.
The Sheffield Gene Therapy Innovation and Manufacturing Centre (GTIMC) will be one of three cutting-edge hubs in the UK dedicated to advancing the clinical development of new genetic treatments.
Gene therapy is a promising treatment option for a number of diseases that currently have no other cures including inherited disorders.
The Sheffield Hub, which is the first in the north of England, is part of an £18 million network created by LifeArc and the Medical Research Council (MRC), with support from the Biotechnology and Biological Sciences Research Council (BBSRC) A pioneering gene therapy innovation centre at the University of Sheffield is set to advance scientific discoveries into promising treatment options for millions of patients with life-threatening diseases which will open in Summer 2022. The GTIMC is currently under construction on the site of the University of Sheffield’s Innovation District close to the centres of Sheffield and Rotherham and within easy reach of major transportation corridors and regional shopping and entertainment complexes.
The centre will include a cutting-edge GMP (good manufacturing practice) facility that will support gene therapy projects emerging from universities across the UK.
The facility will utilise highly efficient processes to manufacture clinical grade adeno-associated viruses (AAV) and provide all the necessary quality assurance, regulatory certification and governance for human trials at Advanced Therapies Treatment Centres and NHS hospital sites.
The Process Development Scientist will support the technology transfer of AAV production methods to the GTIMC from collaborator sites. Once these transfers are complete the post holder will be responsible for scale up of these processes, vector manufacturing activities and process development research, at all times adhering to the relevant GMP standards required.
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