We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fundamental to our continued success.
An opportunity has arisen for a highly motivated individual with a background in transcriptomics and cancer to join a diverse team of investigators exploring mechanisms of skin tumour formation in humans. The project is funded by the Myrovlytis Trust, and will take place in the Translational and Clinical Research Institute at Newcastle University.
The post will be led by the Rajan Lab, in collaboration with the Haniffa and Adams Labs, and will focus on the study of a skin tumours in a genetic condition called Birt-Hogg-Dubé (BHD) syndrome. BHD patients carry rare changes in their DNA in a gene called “folliculin”, and are predisposed to develop skin tumours, punctured lungs and kidney cancer. Our understanding as to why certain specific skin tumours develop in BHD patients and what makes them grow is incomplete. You will lead a programme of research on skin tumours and their immune microenvironment from BHD patients to address these questions.
Using novel single cell and spatial transcriptomics that allow detailed study of single cells in skin tumours, the candidate will study skin immune system and the surrounding structures and proteins in the skin. Collectively these approaches will inform the interaction of both skin tumour cells and the tumour microenvironment, information that is increasingly relevant to gain insights into skin tumour growth. You will also generate three dimensional models of BHD skin tumours, integrating the location of key cells discovered from this work.
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This post is fixed term for a period of 30 months.
For informal enquiries contact: Neil Rajan via email: (email@example.com).
- A PhD in relevant area (or be close to submission of a PhD for Research Assistant level)
- Honors degree in relevant subject